发明名称 |
COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY AND FIBROTIC DISORDERS |
摘要 |
Disclosed are compounds and methods for treating inflammatory and fibrotic disorders, including methods of modulating a stress activated protein kinase (SAPK) system with an active compound, wherein the active compound exhibits low potency for inhibition of the p38 MAPK; and wherein the contacting is conducted at a SAPK-modulating concentration that is at a low percentage inhibitory concentration for inhibition of the p38 MAPK by the compound. Also disclosed are derivatives and analogs of pirfenidone, useful for modulating a stress activated protein kinase (SAPK) system.
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申请公布号 |
US2013102597(A1) |
申请公布日期 |
2013.04.25 |
申请号 |
US201213652247 |
申请日期 |
2012.10.15 |
申请人 |
INTERMUNE, INC.;INTERMUNE, INC. |
发明人 |
KOSSEN KARL;SEIWERT SCOTT D.;SEREBRYANY VLADIMIR;RUHRMUND DONALD;BEIGELMAN LEONID;RAVEGLIA LUCA FRANCESCO MARIO;VALLESE STEFANIA;BIANCHI IVANA;HU TAO |
分类号 |
C07D213/63;C07D213/69;C07D213/85;C07D239/36;C07D239/54;C07D251/10;C07D401/04;C07D405/04;C07D405/14;C07D409/04;C07D413/04;C07D413/14;C07D417/04;C07D417/14;C07D471/04 |
主分类号 |
C07D213/63 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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