| 摘要 |
FIELD: medicine.SUBSTANCE: system refers to endocrinology, and can be used for dry powder delivery to the airways. What is presented is an inhalation system comprising a dry powder inhaler and a dry powder. The system comprises a breath-actuated inhaler, or may be configured to release a powder jet. The inhalation system can change the air flow resistance value from approximately 0.065 to approximately 0.200 (kPa)/litre per minute. The powder contains a number of powdered diketopiperazine particles with a geometric mean diameter ranging within 2 mcm to 8 mcm and a geometric standard deviation less than 4 mcm. Powdered diketopiperazine administered per one inhalation and measured in plasma has AUC-more than 2300 ng×min/ml per mg in the dry powder. What is presented is the inhalation system configured to release more than 90% of the dry powder. After one inhalation, diketopiperazine particles are dissolved and absorbed in blood for less than 30 minutes with the peak concentration. The powder may contain a number of powdered insulin particles. Insulin administered per one inhalation and measured in exposed patient's plasma of AUC-makes more than 160 mcUnits×min/ml per a unit of insulin.EFFECT: invention provides creating the inhalation system with the uniform properties of powder delivery, easy to use and configure to allow the patient to comply with the treatment regimen better.18 cl, 11 tbl, 35 dwg, 9 ex |
