Methods To Increase Transgene Expression From Bacterial-Based Delivery Systems By Co-Expressing Suppressors Of The Eukaryotic Type I Interferon Response

摘要

Bacterial delivery systems with improved transgene expression are provided. The recombinant bacterial delivery systems deliver transgenes of interest and suppressors of the eukaryotic Type I interferon response to eukaryotic cells. Suppression of the eukaryotic Type I interferon response allows improved expression of the encoded transgene.