7-N-Heterocyclyl cephalosporins, a process for preparing and a pharmaceutical composition comprising the same.

摘要

Disclosed are antibiotic cephalosporins (I) of the formula: Wherein the stylized radical attached to the 7-amino nitrogen of the cephalosporin moiety represents a nitrogen-containing heterocyclic group (mono- or polycyclic); R is, inter alia, hydrogen, alkyl, heterocyclylalkyl, aryl, alkenyl, aralkyl, -NR2, -OR, COOR, CONR2 or CN; A is conventionally known in the cephalosporin art; and R<2> is H, or loweralkoxyl; X is S, O, CH2, or NR<7> (R<7> is, inter alia, hydrogen, alkyl or aralkyl. Also disclosed are the pharmaceutically acceptable salt and ester derivatives of I; processes for the preparation of such compounds; and pharmaceutical compositions comprising such compounds.