发明名称 CHROMENE DERIVATIVES AND THEIR ANALOGA AS WNT PATHWAY ANTAGONISTS
摘要 Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.
申请公布号 US2013303550(A1) 申请公布日期 2013.11.14
申请号 US201113885127 申请日期 2011.11.11
申请人 BOUTROS MICHAEL;MASKEY RAJENDRA-PRASAD;KOCH CORINNA;FUCHS FLORIAN;STEINBRINK SANDRA;GILBERT DANIEL;RUPRECHT-KARLS-UNIVERSITAT HEIDELBERG;DEUTSCHES KREBSFORSCHUNGSZENTRUM 发明人 BOUTROS MICHAEL;MASKEY RAJENDRA-PRASAD;KOCH CORINNA;FUCHS FLORIAN;STEINBRINK SANDRA;GILBERT DANIEL
分类号 C07D491/052;C07D311/92 主分类号 C07D491/052
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