A MICROORGANISM MODIFIED FOR THE PRODUCTION OF 1,3-PROPANEDIOL

摘要

The present invention relates to a modified microorganism for the production of PDO from a carbon substrate wherein the microorganism comprises a three- step metabolic pathway comprising a first step of conversion of 2,4- dihydroxybutyrate (DHB) to obtain 2-oxo-4-hydroxybutyrate (OHB) by an enzyme having 2,4-DHB dehydrogenase activity, a second step of decarboxylation of the OHB to obtain 3-hydroxypropionaldehyde by an enzyme having 2-oxo-4-hydroxybutyrate decarboxylase activity, and a third step of reduction of the obtained 3-hydroxypropionaldehyde to obtain PDO with an enzyme having 3-hydroxypropionaldehyde reductase activity and the genes enabling the microorganism for the synthesis of DHB.