发明名称 |
A METHOD OF TREATING ANDROGEN RECEPTOR (AR)-POSITIVE BREAST CANCERS WITH SELECTIVE ANDROGEN RECEPTOR MODULATOR (SARMS) |
摘要 |
This invention relates to the treatment of androgen receptor-positive breast cancer in a subject, for example a female subject. Accordingly, this invention provides methods of: a) treating a subject suffering from breast cancer; b) treating a subject suffering from metastatic breast cancer; c) treating a subject suffering from refractory breast cancer; d) treating a subject suffering from AR-positive breast cancer; e) treating a subject suffering from AR-positive refractory breast cancer; f) treating a subject suffering from AR-positive metastatic breast cancer; g) treating a subject suffering from AR-positive and ER-positive breast cancer; h) treating a subject suffering from triple negative breast cancer; i) treating a subject suffering from advanced breast cancer; j) treating a subject suffering from breast cancer that has failed SERM (tamoxifen, toremifene), aromatase inhibitor, trastuzumab (Herceptin, ado-trastuzumab emtansine), pertuzumab (Perjeta), lapatinib, exemestane (Aromasin), bevacizumab (Avastin), and/or fulvestrant treatments; k) treating, preventing, suppressing or inhibiting metastasis in a subject suffering from breast cancer; 1) prolonging survival of a subject with breast cancer, and/or m) prolonging the progression-free survival of a subject with breast cancer; comprising administering to the subject a therapeutically effective amount of a selective androgen receptor modulator (SARM) compound, comprising administering to the subject a therapeutically effective amount of a SARM compound of this invention. |
申请公布号 |
WO2014011220(A2) |
申请公布日期 |
2014.01.16 |
申请号 |
WO2013US29667 |
申请日期 |
2013.03.07 |
申请人 |
GTX, INC.;DALTON, JAMES, T.;STEINER, MITCHELL, S.;NARAYANAN, RAMESH;AHN, SUNJOO |
发明人 |
DALTON, JAMES, T.;STEINER, MITCHELL, S.;NARAYANAN, RAMESH;AHN, SUNJOO |
分类号 |
C07C271/02;A61K31/325;A61K45/06 |
主分类号 |
C07C271/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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