发明名称 |
NICLOSAMIDE AND ITS DERIVATIVES FOR USE IN THE TREATMENT OF SOLID TUMORS |
摘要 |
The present invention relates to novel therapeutic uses of niclosamide for the treatment of cancer. In particular, a combination of niclosamide or one of its derivatives with an alkylating agent is provided for the treatment of solid tumors. Moreover, niclosamide or one of its derivatives can be used for the treatment of solid tumors characterized by underexpression of NFKBIA. Finally, the invention relates to diagnostic methods for determining whether treatment with niclosamide alone or in combination with an alkylating agent is suitable for a cancer patient. |
申请公布号 |
WO2014023732(A1) |
申请公布日期 |
2014.02.13 |
申请号 |
WO2013EP66484 |
申请日期 |
2013.08.06 |
申请人 |
LIFE & BRAIN GMBH;RHEINISCHE FRIEDRICH-WILHELMS UNIVERSITAET |
发明人 |
SCHEFFLER, BJOERN;GLAS, MARTIN |
分类号 |
A61K31/165;A61K31/167;A61K31/4188;A61K45/06;A61P35/00 |
主分类号 |
A61K31/165 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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