发明名称 |
Preparation of monospecific male-specific antibody and the use thereof for increasing the percentage of mammalian offspring of either sex |
摘要 |
A method of manufacturing and a raw material and its useage are disclosed for increasing the percentage of mammalian offspring of either sex. The process of use utilizes a male-specific antibody coupled to a solid-phase immunoabsorbent material to effect a separation of sex-determining spermatozoa derived from a semen suspension. The male-specific antibody selectively binds male-determining spermatozoa, while the female-determining spermatozoa remain not bound and are recoverable. A male specific antibody that is monospecific is prepared from male cells subjected to a multistep process which includes using said cells for the hyperimmunization of a female species and the preparation of an antiserum which is purified as to specificity by a multiplicity of absorptions against female cells. The antiserum is fractionated to yield male specific monospecific immunoglobulin which may be used to effect a separation of sex determining spermatozoa.
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申请公布号 |
US4448767(A) |
申请公布日期 |
1984.05.15 |
申请号 |
US19800117341 |
申请日期 |
1980.02.15 |
申请人 |
SUMAR CORPORATION |
发明人 |
BRYANT, BERNARD J. |
分类号 |
A61K39/395;A01K67/02;A61K35/52;A61K38/00;A61P13/02;A61P15/00;G01N33/53;G01N33/569;(IPC1-7):A61K39/00;A61K35/48 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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