COMBINED USE OF AMIDES OF MONO- AND DICARBOXYLIC ACIDS AND SILYMARIN IN THE TREATMENT OF RENAL DISEASES

摘要

A therapy for renal diseases characterized by alterations of the kidney function, such as Chronic Kidney Disease (CKD), acute and chronic renal impairment, and renal diseases that develop in diabetic patients or in patients who underwent an anticancer chemotherapic treatment with a platinum derivative. The invention is a combination of compounds selected from mono- or diamide of a C12-C20 monocarboxylic acid, saturated or monounsaturated, or a C4-C14 dicarboxylic acid, saturated or monounsaturated, with an aminoalkanol, and compounds selected from Silymarin, derivatives thereof or conjugates or complexes thereof, for use in the treatment of renal diseases. The mono- or diamide of a C12-C20 monocarboxylic acid, saturated or monounsaturated, or of a C4-C14 dicarboxylic acid, saturated or monounsaturated, with an aminoalkanol and said Silymarin, derivatives thereof or conjugates or complexes thereof are formulated for a separate, sequential, concomitant administration or in admixture, also in a co-micronized or co-ultra-micronized form.

主权项

1. A combination of one or more compounds selected from amide of a C12-C20 monocarboxylic acid, saturated or monounsaturated, or a mono- or diamide of a C4-C14 dicarboxylic acid, saturated or monounsaturated, with an aminoalkanol, and of one or more compounds selected from Silymarin, derivatives thereof or conjugates or complexes thereof, for use in the treatment of renal diseases, wherein said amide of a C12-C20 monocarboxylic acid, saturated or monounsaturated, or a mono- or diamide of a C4-C14 dicarboxylic acid, saturated or monounsaturated, with an aminoalkanol and said Silymarin, derivatives thereof or conjugates or complexes thereof, are formulated for a separate, sequential, concomitant administration or in admixture.