| 主权项 |
1. A compound of formula (I), wherein A and A′ are independently from each other —CH2— or —CH2—CH2—; R is selected from —NR1R2, —NR3R4R5(+)Z1(−) and —OR13; X is halogen; Z1(−) is a halogen anion or an organic acid anion; Z2(−) is a halogen anion or an organic acid anion; Z3(−) is a halogen anion or an organic acid anion; Z4(−) is a halogen anion or an organic acid anion; R1 and R2 are selected independently from each other from
H, —C(NH2)NH, —CN(CH3)2N(CH3)2+Z2−, —C1-3-alkyl, —C2-4-alkyl-N(CH3)2, —C1-3-alkyl-phenyl-R12, —C1-3-alkyl-COOH, —C1-4-alkyl-CO—Y2—R11, —CO-phenyl-CO—O—R13, —CO—C1-4-alkyl, —CO—C1-3-alkyl-NR6R7, —CO—C1-3-alkyl-N(CH3)3+Z3−, —CO—C1-4-alkyl-Y1—R9, —CO—O—C1-4-alkyl-R8, —CO—NH—C3-7-cycloalkyl, —CO—NH—C1-4-alkyl, —CH2—CO—O—C1-3-alkyl, —CH2—CO—O—C1-3-alkyl-phenyl and —SO2—R10;R6 is selected from —C1-3-alkyl, H, —C1-4-alkyl-OH, —CH2—CO—O—C1-3-alkyl and —CH2COOH;R7 is selected from —C1-3-alkyl, —CO—O—C1-3-alkyl, —C1-4-alkyl-OH,
H, —CH2—CO—O—C1-3-alkyl and —CH2COOH;R8 is H or phenyl;R9 is selected from H, —C1-3-alkyl, OH, —NR6R7 and ═O;R10 is C1-3-alkyl or an optionally substituted N-containing nonaromatic heterocycle;R11 is selected from H, C1-3-alkyl, ═O, —N(CH3)2 and —N(CH3)3+Z4−;R12 is selected from H, halogen, —COOH, —PO(OC1-4-alkyl)OH optionally substituted at the 2, 3 or 4 position of the C1-4-alkyl group by —N(C1-3-alkyl)2 or —N(C1-3-alkyl)3+Z4−, and —PO(OC1-4-alkyl)2, —PO(OH)2;R13 is H or C1-4-alkyl;Y1 is selected from an optionally substituted 5- to 8-membered N-containing nonaromatic heterocycle, —N(C1-3-alkyl)-C2-4-alkyl-N(C1-3-alkyl)2 and —N(C1-3-alkyl)-C2-4-alkyl-N+(C1-3alkyl)3 Z1(−);Y2 is an optionally substituted 5- to 8-membered N-containing nonaromatic heterocycle; or R1 and R2 are together with the nitrogen atom they are attached to an optionally substituted 4-7-membered heterocycle, containing at least one N and optionally one or more heteroatoms selected from the group consisting of piperazino, morpholino, piperidino; thiomorpholino, thiomorpholino-1-oxide, thiomorpholinon-1,1-dioxide, diazepane and pyrrolidino, wherein the nitrogen atoms may be substituted by a group selected from among phenyl, C1-3-alkylsulfonyl, C1-3-alkyl and —CO—C1-3-alkyl; R3, R4 and R5 denote independently from each other —C1-3-alkyl; or tautomers or pharmacologically acceptable acid addition salts thereof. |
