| 主权项 |
1. A compound of formula I:or a pharmaceutically acceptable salt thereof, wherein:
each Z is independently (Alk)n-Rn-(Alk)n-X, wherein each Alk is independently (C1 to C12) alkylene or (C2 to C12) alkenylene, each of which may be optionally substituted; each n is independently 0 or 1; each R is independently optionally substituted arylene or heteroarylene, or optionally substituted cycloalkylene or heterocyclic, —O—, —S—, —(C═O)—, —(C═S)—, —SO2—, —C(═O)O—, —C(═O)NRA—, —C(═S)NRA—, —SO2NRA—, —NRAC(═O)—, —NRASO2— or NRA— wherein RA is hydrogen, C1-C6 alkyl, —C1-C6 alkyl(cycloalkyl), C1-C6 alkyl(C1-C6 alkoxy) or C1-C6 alkoxy; each X is independently halogen, —H, —ORA, NRARA, optionally substituted aryl or heteroaryl, or optionally substituted cycloalkyl or heterocyclic, CN or C(halogen)aHb, where a is 1, 2, or 3, and b is (3-a); Y is optionally substituted aryl or heteroaryl, or optionally substituted cycloalkyl or heterocyclic; and R1 is H or C1-C6 alkyl, with the proviso that the compound is not N-(5-bromo-4-fluoro-1H-pyrrolo[2,3-b]pyridin-3-yl)-1-(4-methoxybenzyl)-1H-pyrazole-4-carboxamide or (R)-tert-butyl 1-(5-bromo-3-(1-(4-methoxybenzyl)-1Hpyrazole-4-carboxamido)-1H-pyrrolo[2,3-b]pyridin-4-yl)piperidin-3-ylcarbamate. |
