| 发明名称 |
ANTI-INFECTIVE COMPOUNDS |
| 摘要 |
The present invention relates to 4H-pyrido[1,2-a]pyrimidin-4-one compounds and their use in the treatment of bacterial infections, in particular Tuberculosis. |
| 申请公布号 |
US2015018543(A1) |
申请公布日期 |
2015.01.15 |
| 申请号 |
US201414263218 |
申请日期 |
2014.04.28 |
| 申请人 |
Institut Pasteur Korea ;INSERM (Institut National de la Sante et de la Recherche Medicale) |
发明人 |
BRODIN Priscille;CHRISTOPHE Thierry;NO Zaesung;KIM Jaeseung;GENOVESIO Auguste;FENISTEIN Denis Philippe Cedric;JEON Heekyoung;EWANN Fanny Anne;KANG Sunhee;LEE Saeyeon;SEO Min Jung;PARK Eunjung;CONTRERAS DOMINGUEZ Monica;NAM Ji Youn;KIM Eun Hye |
| 分类号 |
C12Q1/18;C07D233/84;C07D401/12;C07D471/04;C07C335/40;C07D223/24;C07D409/12;C07D498/04;C07C255/66;C07D251/52;C07D251/66;C07D271/113;C07D417/12 |
主分类号 |
C12Q1/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A screening method comprising the steps of:
(a) batch infection of host cells with fluorescently labeled M. tuberculosis mycobacteria; (b) removing free unbound mycobacteria; (c) adding compounds that are to be tested to a multi-well plate; (d) seeding said host cells infected with fluorescently labeled M. tuberculosis mycobacteria into said multi-well plate containing said compounds; (e) incubating said multi-well plate containing host cells infected with fluorescently labeled M. tuberculosis mycobacteria and said compounds; (f) fluorescently labeling said host cells; and (g) analyzing said multi-well plate using automated confocal microscopy. |
| 地址 |
Seongnam-si KR |
