| 发明名称 |
DENGUE SEROTYPE 2 ATTENUATED STRAIN |
| 摘要 |
The invention relates to live attenuated VDV2 (VERO-Derived Vaccine Dengue serotype 2) strains which have been derived from the wild-type dengue-2 strain 16681 by passaging on PDK and Vero cells and nucleic acids thereof. The invention further relates to a vaccine composition which comprises a VDV2 strain. |
| 申请公布号 |
US2015031857(A1) |
申请公布日期 |
2015.01.29 |
| 申请号 |
US201414450529 |
申请日期 |
2014.08.04 |
| 申请人 |
Sanofi Pasteur ;Centers for Disease Control and Prevention |
发明人 |
KINNEY Richard;Kinney Claire Y.H.;Barban Veronique;Lang Jean;Guy Bruno |
| 分类号 |
C07K14/005;A61K39/12;C12N7/00 |
主分类号 |
C07K14/005 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated polyprotein encoded by SEQ ID No.1, or fragments thereof that comprise at least an arginine at position 9 of M protein, and/or a glutamic acid at position 228 of E protein, and/or a threonine at position 69 of NS3 protein, and/or a histidine at position 181 of NS3 protein, and/or a lysine at position 541 of NS5 protein, and/or a threonine at position 832 of NS5 protein. |
| 地址 |
Lyon FR |
