| 发明名称 |
COMPUTATIONALLY OPTIMIZED BROADLY REACTIVE ANTIGENS FOR INFLUENZA |
| 摘要 |
The development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates is described. The optimized HA protein was developed through a series of HA protein alignments, and subsequent generation of consensus sequences, for clade 2 H5N1 influenza virus isolates. The final consensus HA amino acid sequence was reverse translated and optimized for expression in mammalian cells. Influenza virus-like particles containing the optimized HA protein are an effective vaccine against H5N1 influenza virus infection in animals. |
| 申请公布号 |
US2015030628(A1) |
申请公布日期 |
2015.01.29 |
| 申请号 |
US201414511930 |
申请日期 |
2014.10.10 |
| 申请人 |
University of Pittsburgh - Of the Commonwealth System of Higher Education |
发明人 |
Ross Ted M.;Giles Brendan M. |
| 分类号 |
A61K39/145;A61K39/39;C12N7/00;C07K14/005 |
主分类号 |
A61K39/145 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An influenza virus-like particle (VLP) comprising an influenza hemagglutinin (HA) polypeptide, wherein the amino acid sequence of the HA polypeptide is at least 99% identical to SEQ ID NO: 2. |
| 地址 |
Pittsburgh PA US |
