s-TRIAZINE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS AND METHODS OF USING THE SAME

摘要

Novel s-triazine compounds are disclosed that have a formula represented by the following:;;L1, L2, L3, R1, R2, R3, R4, R5a, R5b, and R5c are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, where microbial infection is either a direct cause or a related condition.

主权项

1. A s-triazine compound having a formula: wherein each L1 and L2 is independently selected from a single bond, or C1-C4 alkylene; L3 is selected from C2-C6 alkylene, C2-C6 alkenyl, and C2-C6 alkynyl; each R1 and R2 is independently selected from hydrogen, and substituted or unsubstituted C1-C6 alkyl; or R1 and R2 may join together to form a 4-7 membered heterocycloalkyl; or R1 is H; and R2 is —C(═NH)—NH2; R3 is R4; or R3 is selected from substituted or unsubstituted aryl and substituted or unsubstituted heteroaryl; R4 is substituted or unsubstituted each X is C or N; provided that no more than three Xs are N at one time;each Y is C or N; provided that no more than three Ys are N at one time;R6 is H or substituted or unsubstituted C1-C6 alkyl; each R5a, R5b, or R5c is independently H or substituted or unsubstituted C1-C6 alkyl; or a pharmaceutically acceptable salt, solvate or prodrug thereof; and stereoisomers, isotopic variants and tautomers thereof.