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1. A phosphate compound selected from those of formula (I): wherein:
X and Y represent a carbon atom or a nitrogen atom, wherein X and Y may not simultaneously represent two carbons atoms or two nitrogen atoms;A1 and A2, together with the atoms carrying them, form an optionally substituted, aromatic or non-aromatic heterocycle Het composed of 5, 6 or 7 ring members which may have, in addition to the nitrogen represented by X or by Y, from one to 3 heteroatoms selected independently from oxygen, sulphur and nitrogen, wherein the nitrogen atom may be substituted by a hydrogen atom, a linear or branched (C1-C6)alkyl group or a —C(O)—O-Alk group wherein Alk is a linear or branched (C1-C6)alkyl group,or A1 and A2 independently of one another represent a hydrogen atom, a linear or branched (C1-C6)polyhaloalkyl, a linear or branched (C1-C6)alkyl group or a cycloalkyl;T represents a hydrogen atom, a linear or branched (C1-C6)alkyl group optionally substituted by from one to three halogen atoms, a (C1-C4)alkyl-NR1R2 group, or a (C1-C4)alkyl-OR6 group;R1 and R2 independently of one another represent a hydrogen atom or a linear or branched (C1-C6)alkyl group,or R1 and R2 together with the nitrogen atom carrying them form a heterocycloalkyl;R3 represents a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a cycloalkyl group, a (C3-C10)cycloalkyl-(C1-C6)alkyl group wherein the alkyl moiety is linear or branched, a heterocycloalkyl group, an aryl group or a heteroaryl group, wherein one or more of the carbon atoms of the preceding groups, or of their possible substituents, may be deuterated;R4 represents an aryl group, a heteroaryl group, a cycloalkyl group or a linear or branched (C1-C6)alkyl group, wherein one or more of the carbon atoms of the preceding groups, or of their possible substituents, may be deuterated;R5 represents a hydrogen atom, a halogen atom, a linear or branched (C1-C6)alkyl group, or a linear or branched (C1-C6)alkoxy group;R6 represents a hydrogen atom or a linear or branched (C1-C6)alkyl group;Ra, Rb, Rc and Rd, each independently of the others, represent, a hydrogen atom, a linear or branched (C1-C6)alkyl, a linear or branched (C2-C6)alkenyl, a linear or branched (C2-C6)alkynyl, an aryl, a heteroaryl, a halogen atom, a linear or branched (C1-C6)alkoxy group, a hydroxy group, a linear or branched (C1-C6)polyhaloalkyl group, a trifluoromethoxy group, —NR7R7′, nitro, R7—CO—(C0-C6)alkyl-, R7—CO—NH—(C0-C6)alkyl-, NR7R7′—CO—(C0-C6)alkyl-, NR7R7′—CO—(C0-C6)alkyl-O—, R7—SO2—NH—(C0-C6)alkyl-, R7—NH—CO—NH—(C0-C6)alkyl-, R7—O—CO—NH—(C0-C6)alkyl-, a heterocycloalkyl group, or the substituents of one of the pairs (Ra,Rb), (Rb,Rc) or (Rc,Rd) together with the carbon atoms carrying them form a ring composed of from 5 to 7 ring members, which ring may have from one to 2 hetero atoms selected from oxygen and sulphur, wherein one or more carbon atoms of the ring defined hereinbefore may be deuterated or substituted by from one to 3 groups selected from halogen and linear or branched (C1-C6)alkyl;R7 and R7′ independently of one another represent a hydrogen atom, a linear or branched (C1-C6)alkyl, a linear or branched (C2-C6)alkenyl, a linear or branched (C2-C6)alkynyl, an aryl or a heteroaryl, or R7 and R7′ together with nitrogen atom carrying them form a heterocycle composed of from 5 to 7 ring members, wherein at least one of the carbon atoms of the compound of formula (I) is substituted by one of the following phosphate groups: —OPO(OM)(OM′), —OPO(OM)(O−M1+), —OPO(O−M1+)(O−M2+), —OPO(O−)(O−)M32+, —OPO(OM)(O[CH2CH2O]nCH3), or —OPO(O−M1+)(O[CH2CH2O]nCH3), wherein M and M′ independently of one another represent a hydrogen atom, a linear or branched (C1-C6)alkyl group, a linear or branched (C2-C6)alkenyl group, a linear or branched (C2-C6)alkynyl group, a cycloalkyl or a heterocycloalkyl both composed of 5 or 6 ring members, and wherein M1+ and M2+ independently of one another represent a pharmaceutically acceptable monovalent cation, and M32+ represents a pharmaceutically acceptable divalent cation and n is an integer from 1 to 5, it being understood that:
“aryl” means a phenyl, naphthyl, biphenyl or indenyl group,“heteroaryl” means any mono- or bi-cyclic group composed of from 5 to 10 ring members, having at least one aromatic moiety and containing from 1 to 4 hetero atoms selected from oxygen, sulphur and nitrogen (including quaternary nitrogens),“cycloalkyl” means any mono- or bi-cyclic, non-aromatic, carbocyclic group containing from 3 to 10 ring members,“heterocycloalkyl” means any mono- or bi-cyclic, non-aromatic, condensed or spiro group composed of 3 to 10 ring members and containing from 1 to 3 hetero atoms selected from oxygen, sulphur, SO, SO2 and nitrogen, wherein the aryl, heteroaryl, cycloalkyl and heterocycloalkyl groups so defined and the groups alkyl, alkenyl, alkynyl and alkoxy may be optionally substituted by from 1 to 3 groups selected from optionally substituted, linear or branched (C1-C6)alkyl, (C3-C6)spiro, linear or branched, optionally substituted (C1-C6)alkoxy, (C1-C6)alkyl-S—, hydroxy, oxo (or N-oxide where appropriate), nitro, cyano, —COOR′, —OCOR′, NR′R″, linear or branched (C1-C6)polyhaloalkyl, trifluoromethoxy, (C1-C6)alkylsulphonyl, halogen, optionally substituted aryl, heteroaryl, aryloxy, arylthio, cycloalkyl, heterocycloalkyl optionally substituted by one or more halogen atoms or alkyl groups, wherein R′ and R″ independently of one another represent a hydrogen atom or an optionally substituted, linear or branched (C1-C6)alkyl group, wherein the Het group defined in formula (I) may be optionally substituted by from one to three groups selected from linear or branched (C1-C6)alkyl, hydroxy, linear or branched (C1-C6)alkoxy, NR1′R1″ and halogen, wherein R1′ and R1″ independently of one another represent a hydrogen atom or an optionally substituted, linear or branched (C1-C6)alkyl group, and its enantiomers, diastereoisomers, and addition salts thereof with a pharmaceutically acceptable acid or base. |
