METHODS AND FORMULATIONS FOR CONVERTING INTRAVENOUS AND INJECTABLE DRUGS INTO ORAL DOSAGE FORMS

摘要

Oral dosage compositions for drugs normally given intravenously such as Paclitaxel, containing a plant sterol to enhance solubility and a small intestine efflux inhibitor to prevent P-glycoprotein from being a barrier to absorption.

主权项

1. A drug delivery composition for normally difficultly soluble hydrophobic crystalline drug actives, comprising:
an emulsifier, a plant derived sterol (stanol) or ester derived from the sterol (stanol); a drug active effective amount of a hydrophobic drug; and a small but inhibiting effective amount of an inhibitor of small intestine efflux proteins.