发明名称 |
HUMAN ANTIBODIES AND PROTEINS |
摘要 |
The present invention provides composite proteins, including antibodies, which show reduced immunogenicity. In particular, composite antibodies for use in humans are provided, in particular antibodies which have been modified to remove one or more T-cell epitopes. Methods for generating such proteins are also provided. |
申请公布号 |
US2015031860(A1) |
申请公布日期 |
2015.01.29 |
申请号 |
US201414324520 |
申请日期 |
2014.07.07 |
申请人 |
Jones Timothy David;Baker Matthew Paul |
发明人 |
Jones Timothy David;Baker Matthew Paul |
分类号 |
C07K16/42;C07K16/24;C07K16/28 |
主分类号 |
C07K16/42 |
代理机构 |
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代理人 |
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主权项 |
1. A modified antibody or antigen-binding fragment thereof wherein the heavy and light chain variable regions of the modified antibody or antigen-binding fragment are each composed of two or more segments of amino acid sequence from one or more other antibodies or antigen-binding fragments, whereby the segments are neither whole CDRs nor framework regions. |
地址 |
Cambridge GB |