SELECTIVE DELIVERY MOLECULES AND METHODS OF USE

摘要

Disclosed herein is a selective delivery molecule comprising: (a) an acidic sequence (portion A) which is effective to inhibit or prevent the uptake into cells or tissue retention, (b) a molecular transport or retention sequence (portion B), and (c) a linker between portion A and portion B, and (d) at least one cargo moiety.

主权项

1. A selective delivery molecule of Formula I, having the structure:
[DA-cA]-A-[cM-M]-X-B-[cB-DB]  Formula Iwherein,
X is a cleavable linker; A is a peptide with a sequence comprising 5 to 9 acidic amino acids; B is a peptide with a sequence comprising 7 to 9 basic amino acids; cA, cB, and cM are each independently 0-1 amino acid, wherein the amino acid is a naturally-occurring amino acid or non-naturally-occurring amino acid; M is a polyethylene glycol (PEG) polymer; and DA and DB are each independently an imaging agent; andwherein [cM-M] is bound to at any position on A or X, [DA-CA] is bound to any amino acid on A or X, and [cB-DB] is bound to any amino acid on B.