| 发明名称 |
HMGN2 PEPTIDES AND RELATED MOLECULES THAT SELECTIVELY HOME TO TUMOR BLOOD VESSELS AND TUMOR CELLS |
| 摘要 |
The present invention provides a conjugate which contains a therapeutic moiety linked to a homing molecule that selectively homes to tumor blood vessels and tumor cells and that specifically binds the receptor bound by peptide KDEPQRRSARLSAKPAPPKPEPKPKKAPAKK (SEQ ID NO: 9). Methods of directing a conjugate of the invention to tumor blood vessels and tumor cells and of using a conjugate to treat cancer also are provided. |
| 申请公布号 |
US2015031851(A1) |
申请公布日期 |
2015.01.29 |
| 申请号 |
US201314067858 |
申请日期 |
2013.10.30 |
| 申请人 |
SANFORD-BUMHAM MEDICAL RESEARCH INSTITUTE |
发明人 |
RUOSLAHTI ERKKI;PORKA KIMMO;CHRISTIAN SVEN |
| 分类号 |
A61K47/48;C07K7/06 |
主分类号 |
A61K47/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated homing peptide comprising the amino acid sequence PQRRSARLSA (SEQ ID NO: 11) said peptide having a length of less than 200 residues, wherein said peptide specifically binds nucleolin expressed on the surface of a tumor cell. |
| 地址 |
LA JOLLA CA US |
