Automated Measurement of Changes in Retinal, Retinal Pigment Epithelial, or Choroidal Disease

摘要

A method for for automatically measuring changes in retinal, retinal pigment epithelial, or choroidal disease includes retrieving a set of images of a fundus and selecting a plurality of images from the set of images. The plurality of images are co-registered and pre-processed such that the quality, contrast, and gain of each of the plurality of images is made similar. Then, a comparison is made between the plurality of images to determine a change in retinal, retinal pigment epithelial, or choroidal disease, wherein the change in retinal, retinal pigment epithelial, or choroidal disease is determined based on various disease metrics. Finally, an indication of the change in retinal, retinal pigment epithelial, or choroidal disease is generated for display to a user on a computing device.

主权项

1. A computer-implemented method for automatically measuring changes in retinal, retinal pigment epithelial, or choroidal disease, the method comprising:
retrieving, with one or more processors, a set of images of a fundus; selecting, by the one or more processors, a plurality of images from the set of images, wherein the plurality of images includes images of the fundus captured at successive times; co-registering, by the one or more processors, the plurality of images, wherein co-registering the plurality of images includes:
detecting a plurality of blood vessel locations within each of the plurality of images,correlating the detected plurality of blood vessel locations in one of the plurality of images with a plurality of blood vessel locations in the remaining plurality of images, andtransforming the remaining plurality of images such that blood vessel locations in the remaining plurality of images are proximate to the detected plurality of blood vessel locations in the one of the plurality of images; pre-processing, by the one or more processors, the plurality of images such that the quality, contrast, and gain of each of the plurality of images is made similar; performing a comparison, by the one or more processors, of the plurality of images to determine a change in retinal, retinal pigment epithelial, or choroidal disease, wherein the change in retinal, retinal pigment epithelial, or choroidal disease is determined based on various disease metrics; and generating, by the one or more processors, an indication of the change in retinal, retinal pigment epithelial, or choroidal disease to be displayed to a user of a computing device.