| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for treating abnormal cell proliferation, neurological disorders, aberrant cell regulation, diseases and the like in which up-regulation or inhibition of targeted nucleic acid is effective, by using sequence-specific small interfering RNA (siRNA) which controls expression of a gene product, where siRNA knocks down the antisense transcript and regulates expression of its sense partner, which is discordant (antisense knockdown results in sense transcript elevation) or concordant (antisense knockdown results in concomitant sense transcript reduction.SOLUTION: Provided is a pharmaceutical composition comprising a siRNA molecule of a specified sequence which targets an overlapped region of sense/antisense loci. |
