发明名称 |
Computationally optimized broadly reactive antigens for influenza |
摘要 |
<p>Described herein is the development of a computationally optimized influenza HA protein that elicits broadly reactive immune response to all H5N1 influenza virus isolates. The optimized HA protein was developed through a series of HA protein alignments, and subsequent generation of consensus sequences, for clade 2 H5N1 influenza virus isolates. The final consensus HA amino acid sequence was reverse translated and optimized for expression in mammalian cells. It is disclosed herein that influenza virus-like particles containing the optimized HA protein are an effective vaccine against H5N1 influenza virus infection in animals.</p> |
申请公布号 |
AU2011302360(B2) |
申请公布日期 |
2015.01.29 |
申请号 |
AU20110302360 |
申请日期 |
2011.09.09 |
申请人 |
UNIVERSITY OF PITTSBURGH-OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION |
发明人 |
ROSS, TED M.;GILES, BRENDAN M. |
分类号 |
C12N15/33;C12N15/44;C12N15/63 |
主分类号 |
C12N15/33 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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