TISSUE-ENGINEERED CONSTRUCTS

摘要

The present invention provides constructs including a tubular biodegradable polyglycolic acid scaffold, wherein the scaffold may be coated with extracellular matrix proteins and substantially acellular. The constructs can be utilized as an arteriovenous graft, a coronary graft, a peripheral artery bypass conduit, or a urinary conduit. The present invention also provides methods of producing such constructs.

主权项

1. A construct comprising a tubular biodegradable non-woven polyglycolic acid scaffold comprising non-biodegradable polyethylene terephthalate supports at each end of the tubular biodegradable polyglycolic acid scaffold, wherein the density of the polyglycolic acid is about 45 mg/cc to about 75 mg/cc and said density is uniform across the entire tubular scaffold, wherein the thickness of the polyglycolic acid is about 0.8 to about 1.2 mm, wherein the thickness of the fibers within the polyglycolic acid is about 5 to about 20 μm, and wherein the porosity of the polyethylene terephthalate is >200 cc/min/cm2 and the supports permit the attachment and growth of cells.