| 发明名称 |
CITRULLINATED BRAIN AND NEUROLOGICAL PROTEINS AS BIOMARKERS OF BRAIN INJURY OR NEURODEGENERATION |
| 摘要 |
The present invention relates to the field of biomarkers. More specifically, the present invention relates to biomarkers useful in diagnosing brain injury or neurodegeneration. In one embodiment, a method for diagnosing brain injury in a patient comprises the steps of (a) obtaining a sample from the patient; (b) determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and (c) correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis. |
| 申请公布号 |
US2015031048(A1) |
申请公布日期 |
2015.01.29 |
| 申请号 |
US201314384848 |
申请日期 |
2013.03.13 |
| 申请人 |
THE JOHNS HOPKINS UNIVERSITY |
发明人 |
Van Eyk Jennifer E.;Everett Allen Dale;Jin Zhicheng |
| 分类号 |
G01N33/68;H01J49/00;G01N33/53 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for diagnosing brain injury in a patient comprising the steps of:
a. obtaining a sample from the patient; b. determining the ratio of citrullinated to unmodified arginine residues at one or more arginine residues of one or more brain injury biomarker proteins; and c. correlating the ratio to a patient having brain injury or to a patient not having brain injury, thereby providing the diagnosis. |
| 地址 |
Baltimore MD US |
