TRANSPORT PROTEIN WHICH IS USED TO INTRODUCE CHEMICAL COMPOUNDS INTO NERVE CELLS

摘要

The invention relates to a transport protein which can be obtained by modifying the heavy chain of the neurotoxin formed by Clostridium botulinum. The protein binds specifically to nerve cells with a higher affinity as the native neurotoxin. The invention also relates to a method for the production of transport protein, the nucleic acids coding for the transport protein, the transport protein containing pharmaceutical and cosmetic compositions and use thereof.

主权项

1. A transport protein, obtained by modification of the heavy chain of a Clostridium botulinum type A (BoNT/A), said heavy chain comprising a HN-fragment and a HC-fragment, wherein said HC-fragment includes a HCC-fragment and a HCN-fragment, wherein the HC-fragment of the BoNT/A heavy chain is substituted by the HC-fragment of a different Clostridium neurotoxin type, wherein said transport protein binds to a motor neuron.