SYSTEMS AND METHODS FOR SELECTING AND ANALYZING PARTICLES IN A BIOLOGICAL TISSUE

摘要

Systems and methods are disclosed for jointly presenting and analyzing morphological characteristics and biomarker expression levels of a biological sample. The systems and methods may utilize a morphological selection component to isolate a population of biological particles in a biological sample for exclusion from further processing. In addition, the systems and methods may simultaneously render morphological and statistical representations of the biological sample on a user interface.

主权项

1. A computer-implemented method for selectively displaying representations of biological units of interest in biological tissue, the method comprising:
rendering a graphical user interface on a visual display device; rendering, on the graphical user interface, a field of view selection component allowing a user to select a field of view from a data set comprising tissue profile data including registered multiplexed biomarker images capturing expression of a plurality of biomarkers in a plurality of fields of view of biological tissue, wherein individual biological units in the plurality of fields of view are delineated; in response to user input selecting the field of view corresponding to a biological tissue at the field of view selection component, rendering, on the graphical user interface, a first image of the selected field of view corresponding to the biological tissue, the first image representing expression levels of a first biomarker and including representations of individual biological units in the biological tissue; and rendering, on the graphical user interface, a morphological feature selection component allowing a user to select from among the delineated individual biological units a first morphological feature meeting at least one first morphological feature criteria; in response to user input selecting a first morphological feature meeting at least one first morphological feature criteria, identifying a first set of biological units represented in the first image that meet the at least one first morphological feature criteria in the first image of the selected field of view as biological units for exclusion from further analysis.