发明名称 |
HUMANIZED ANTI-TRKA ANTIBODIES WITH AMINO ACID SUBSTITUTIONS |
摘要 |
The present invention relates to antibodies directed against TrkA receptor and their uses, including humanized anti-TrkA antibodies. More specifically, the present invention relates to humanized anti-TrkA antibodies with enhanced inhibitory properties comprising a heavy chain variable region, a light chain, variable region, a human light chain constant region and a variant human IgG4 heavy chain constant region which exhibit altered exchange properties. |
申请公布号 |
SG11201408037S(A) |
申请公布日期 |
2015.01.29 |
申请号 |
SG11201408037S |
申请日期 |
2013.06.07 |
申请人 |
GLENMARK PHARMACEUTICALS S.A. |
发明人 |
BLEIN, STANISLAS;OLLIER, ROMAIN;SKEGRO, DARKO |
分类号 |
C07K16/28;A61K39/395;A61P29/00 |
主分类号 |
C07K16/28 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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