| 发明名称 |
METHOD FOR PREDICTING AND DETECTING TUMOR METASTASIS |
| 摘要 |
The invention provides a method of determining the prognosis of cancer in a subject. The method comprises (a) obtaining a sample from the subject, (b) analyzing the sample for the expression level of a carboxypeptidase E (CPE) splice variant, and (c) correlating the expression level in the sample with the prognosis of cancer in the subject. The invention further provides a method of diagnosing cancer, methods of treatment, kits for detecting mRNA expression of a CPE-ΔN, and inhibitors of CPE-ΔN and compositions thereof. |
| 申请公布号 |
US2015031744(A1) |
申请公布日期 |
2015.01.29 |
| 申请号 |
US201414337408 |
申请日期 |
2014.07.22 |
| 申请人 |
The United States of America,as represented by the Secretary,Department of Health Human Services |
发明人 |
Loh Yoke Peng;Cawley Niamh X.;Murthy Saravana Radha Krishna;Lee Terence K. |
| 分类号 |
C12Q1/68;A61K45/06;G01N33/573;C12N15/113 |
主分类号 |
C12Q1/68 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of determining the prognosis of cancer in a subject, the method comprising
(a) obtaining a sample from the subject, (b) analyzing the sample for an expression level of a carboxypeptidase E (CPE) splice variant that lacks the N terminus (CPE-ΔN), and (c) correlating the expression level of CPE-ΔN in the sample to the prognosis of cancer in the subject. |
| 地址 |
Bethesda MD US |
