COMPOSITIONS OF DUAL THYROINTEGRIN ANTAGONISTS AND USE IN VASCULAR-ASSOCIATED DISORDERS

摘要

A dual thyrointegrin antagonist and a method for treating an angiogenesis-mediated disorder and/or a hyperthyroidism disorders by introducing the dual thyrointegrin antagonist into animals (e.g., mammals, human beings). The dual thyrointegrin antagonist includes a chemical structure having a thyroid hormone antagonist and αvβ3 integrin antagonist in the same molecule.

主权项

1. A dual thyrointegrin antagonist, comprising a chemical structure of wherein R is selected from the group consisting of hydrogen, methyl, ethyl, propyl, and isopropyl; wherein a group X is —(CH2)nNH2 such that n is 3, 4, or 5; wherein a first condition, a second condition, a third condition, a fourth condition, or a fifth condition is satisfied; wherein the first condition is that (R1 is X, R2 is I, and R3 is I), (R1 is I, R2 is X, and R3 is I), or (R1 is I, R2 is I, and R3 is X); wherein the second condition is that R1, R2, and R3 are each selected from the group consisting of X, H, and I such that R1, R2, and R3 differ from each other; wherein the third condition is that R1, R2, and R3 are each selected from the group consisting of X, OH, and I such that R1, R2, and R3 differ from each other; wherein the fourth condition is that R1, R2, and R3 are each selected from the group consisting of X, OH, and H such that R1, R2, and R3 differ from each other; wherein the fifth condition is that R1 is I, R3, is I, and R2 is selected from the group consisting of wherein t-Boc stands for tert-Butyloxycarbonyl.