发明名称 |
STEROLS DERIVATIVE, AND PREPARATION METHOD AND PURPOSE THEREOF |
摘要 |
The present invention pertains to pharmaceutical chemical field, and relates to a sterol derivative as well as preparation method and uses thereof. Specifically, the present invention relates to a compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ═O(carbonyl), H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ═O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. The compound of the present invention can inhibit HMG-CoA reductase, tumor cells and lipase effectively, and is a potential drug for reducing blood-fat, antitumors, or for losing weight.; |
申请公布号 |
US2015031657(A1) |
申请公布日期 |
2015.01.29 |
申请号 |
US201214368494 |
申请日期 |
2012.12.25 |
申请人 |
BEIJING PEKING UNIVERSITY WBL BIOTECH CO., LTD. |
发明人 |
Duan Zhenwen;Guo Shuren;Li Xuemei |
分类号 |
C07J71/00 |
主分类号 |
C07J71/00 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of Formula I, or a pharmaceutically acceptable salt, ester or ether thereof, wherein, R1 is selected from the group consisting of —OH, ═O, H, and C1-C3 alkyl; R2 is selected from the group consisting of —OH, H, and C1-C3 alkyl; R3 is selected from the group consisting of —OH, ═O, H, and C1-C3 alkyl; R4 is selected from the group consisting of —OH, H, and C1-C3 alkyl; and none, one, two, three or four of R1, R2, R3, and R4 are —OH. |
地址 |
Beijing CN |