BACTERIAL CELL HAVING ENHANCED SUCCINIC ACID PRODUCTION AND A METHOD FOR PRODUCING THE SUCCINIC ACID USING THE SAME

摘要

A genetically engineered bacterial cell wherein activity of a pathway in the cell of converting α-ketoglutarate into succinate semialdehyde; or activity of succinyl semialdehyde dehydrogenase in the cell is increased compared to the activity in a non-genetically engineered cell of the same type, and a method of producing succinic acid by using the same.

主权项

1. A genetically engineered bacterial cell, wherein activity of a pathway in the cell of converting α-ketoglutarate (AKG) into succinate semialdehyde (SSA) or activity of succinyl semialdehyde dehydrogenase (SSADH) in the cell is increased as compared to the activity in a parent cell, wherein the pathway of converting AKG into SSA includes α-ketoglutarate decarboxylase (KGDC); glutamate:succinate semialdehyde transaminase and glutamate decarboxylase; or a combination thereof, and the KGDC catalyzes the conversion of α-ketoglutarate into SSA, and the SSADH catalyzes the conversion of SSA into succinic acid.