| 发明名称 |
DIAGNOSIS AND TREATMENT OF TRAUMATIC BRAIN INJURY |
| 摘要 |
The subject invention identifies CC chemokine ligand 20 (CCL20) as a novel biomarker for diagnosis of traumatic brain injury and/or neurodegeneration in the brain. The subject invention also provides treatment methods for traumatic brain injury and/or neurodegeneration in the brain by modulating systemic and/or brain-specific CCL20-CCR6 signaling. Also provided are uses of CCL20-CCR6 signaling a target for screening for therapeutic agents that are useful for treatment of traumatic brain injury. |
| 申请公布号 |
US2015030609(A1) |
申请公布日期 |
2015.01.29 |
| 申请号 |
US201214006557 |
申请日期 |
2012.05.03 |
| 申请人 |
Mohapatra Subhra;Mohapatra Shyam S.;Pennypacker Keith Ronald;Das Mahasweta;Leonardo Christopher Charles |
发明人 |
Mohapatra Subhra;Mohapatra Shyam S.;Pennypacker Keith Ronald;Das Mahasweta;Leonardo Christopher Charles |
| 分类号 |
G01N33/68;C07K16/24 |
主分类号 |
G01N33/68 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A method of diagnosing whether a subject has traumatic brain injury, comprising:
a) determining CC chemokine ligand 20 (CCL20) level in a biological sample obtained of the subject; and b) comparing the CCL20 level in the biological sample of the subject to a predetermined reference value, and diagnosing the subject as having traumatic brain injury if the CCL20 level in the biological sample of the subject is higher than the predetermined reference value. |
| 地址 |
Lutz FL US |
