FLUOROMETHYL-5,6-DIHYDRO-4H-[1,3]OXAZINES

摘要

The present invention provides a compound of formula (I) having BACE1 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active compounds of the present invention are useful in the therapeutic and/or prophylactic treatment of e.g. Alzheimer's disease.;

主权项

1. A compound of formula I, wherein R is selected from the group consisting of i) aryl, ii) aryl substituted by 1-4 substituents individually selected from cyano, cyano-C1-6-alkyl, halogen, halogen-C1-6-alkoxy, halogen-C1-6-alkyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C2-6-alkynyl-C1-6-alkoxy, C2-6-alkynyl and C1-6-alkyl, iii) heteroaryl, and iv) heteroaryl substituted by 1-4 substituents individually selected from cyano, cyano-C1-6-alkyl, halogen, halogen-C1-6-alkoxy, halogen-C1-6-alkyl, C1-6-alkoxy, C1-6-alkoxy-C1-6-alkyl, C2-6-alkynyl-C1-6-alkoxy, C2-6-alkynyl and C1-6-alkyl; R2 is selected from the group consisting of i) hydrogen, ii) C1-6-alkyl, and iii) halogen; R3 is selected from the group consisting of i) C1-6-alkyl, and ii) halogen-C1-6-alkyl, R4 is halogen-C1-6-alkyl; or pharmaceutically acceptable salts thereof.