Diphenyl sulfide derivative and pharmaceutical product which contains same as active ingredient

摘要

The disclosure relates to a diphenyl sulfide derivative represented by general formula (1) which is useful as a pharmaceutical product that has excellent S1P3 antagonist activity, wherein R1 represents an alkoxy group having 1-6 carbon atoms, R2 represents a propyl group or an allyl group, X represents methylene or an oxygen atom, and Z represents a halogen atom. These diphenyl sulfide derivatives are suitable for treating sepsis, respiratory disorders or diseases, cytokine storm caused by an influenza virus or RS virus infection, arteriosclerosis, blood vessel intimal thickening, solid tumors, diabetic retinopathy, rheumatoid arthritis, cardiac arrest, ischemia-reperfusion disorders, cerebral bloodvessel spasms after subarachnoid bleeding, angina pectoris or myocardial infarction caused by coronary vessel spasms, glomerulonephritis, thrombosis, lung disease caused by pulmonary edema, cardiac arrhythmia, eye disease, eye hypertension, glaucoma, glaucomatous retinopathy, optic neuropathy, or macula-lutea degeneration.