摘要 |
<p>The present invention provides an oral formulation which contains a secondary wet granule produced by coating a primary wet granule with a mixed aqueous solution of an a-glycosidase inhibitor and hydroxypropyl cellulose, wherein said primary wet granule is produced by combining a mixed powder comprising metformin and hydroxypropyl cellulose with an aqueous solution of hydroxypropyl cellulose serving as a binding solution. In addition, the present invention provides a method for preparing an oral formulation, comprising the steps of: injecting the mixed powder of metformin and hydroxypropyl cellulose into a fluidized bed granulator, and spraying the aqueous solution of hydroxypropyl cellulose onto the mixed powder to produce a primary wet granule; and spraying the mixed aqueous solution of a-glycosidase inhibitor and hydroxypropyl cellulose onto the primary wet granule in the fluidized bed granulator to produce a secondary wet granule.</p> |