TREATMENT OF IL-1βRELATED DISEASES

摘要

PROBLEM TO BE SOLVED: To provide methods that directly target an IL-1βligand for treatment and/or prevention of type 2 diabetes mellitus, insulin resistance, and disease states and conditions characterized by insulin resistance, obesity, hyperglycemia, hyperinsulinemia, and type 1 diabetes mellitus.SOLUTION: The invention provides therapeutic and/or preventing methods of the diseases comprising a step of administering an effective amount of an anti-IL-1βantibody or a fragment thereof to subjects. Further, the methods provided herein are in conjunction with at least one additional treatment method, the additional treatment method comprising a step of administering at least one pharmaceutical composition comprising an active agent other than an IL-1βantibody or a fragment. The methods comprise a drug in which at least one pharmaceutical composition comprising an active agent other than an IL-1βantibody or a fragment is selected from the group consisting of a sulfonylurea, a meglitinide, a biguanide, anα-glucosidase inhibitor, a thiazolidinedione, a glucagon-like peptide, and insulin.