发明名称 |
LIM KINASEMODULATING AGENTS FOR NEUROFIBROMATOSES THERAPY AND METHODS FOR SCREENING FOR SAME |
摘要 |
Disclosed herein are methods of treating a patient at risk of developing or having a neurofibromatosis or a sporadic schwannoma. In exemplary embodiments, the method involves administering to a subject in need an effective amount of a LIMK modulating agent. Also disclosed are compounds newly identified to be inhibitors of Merlin-null Schwann cell proliferation and/or survival. |
申请公布号 |
US2015105441(A1) |
申请公布日期 |
2015.04.16 |
申请号 |
US201314385211 |
申请日期 |
2013.03.13 |
申请人 |
UNIVERSITY OF CENTRAL FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
Fernandez-Valle Cristina |
分类号 |
A61K31/427;A61K31/422;G01N33/50;C12N15/113 |
主分类号 |
A61K31/427 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Orlando FL US |