| 摘要 |
PROBLEM TO BE SOLVED: To provide processes for preparing microparticles using a solvent extraction technique, including controlled addition and/or removal of an extraction phase. ! SOLUTION: The invention relates to a process for producing microparticles comprising steps of: (a) forming an emulsion comprising a first phase comprising an agent, a polymer, and a first solvent for the polymer, in a continuous process medium; and (b) contacting the emulsion in situ with an extraction phase to extract the first solvent from the first phase into the extraction phase to form the microparticles, where a portion of the extraction phase is continuously removed and a supplementary extraction phase fluid is added back into the extraction phase, or the extraction phase fluid is added into the extraction phase over time during the step (b) such that the extraction ratio increases over time during the step (b). ! COPYRIGHT: (C)2015,JPO&INPIT |
