发明名称 IMMUNOMODULATORY COMPOUNDS FOR RESTORING VITAMIN D SENSITIVITY IN VITAMIN D RESISTANT TUMOR CELLS
摘要 <p>PROBLEM TO BE SOLVED: To provide a method for restoring vitamin D sensitivity in vitamin D resistant tumor cells.SOLUTION: The invention also provides a method for treating, preventing or managing cancer by using an immuno-modulatory compound with a vitamin D agent. Also disclosed are a pharmaceutical composition and a single unit dosage form suitable for use in the method provided in the specification. In another embodiment, provided is a method for treating, managing or preventing a cancer refractory to vitamin D treatment, which method comprises administering to a patient having such a cancer a certain amount of the immuno-modulatory compound or a pharmaceutically acceptable salt, solvate or stereoisomer thereof in combination with a vitamin D agent.</p>
申请公布号 JP2015145432(A) 申请公布日期 2015.08.13
申请号 JP20150101583 申请日期 2015.05.19
申请人 CELGENE CORP 发明人 CAROLE BROSSEAU;JUSTIN BLAKE BARLETT;ANGUS GEORGE DALGLEISH;KAY WINIFRED COLSTON;CHRISTINE GALUSTIAN
分类号 A61K31/59;A61K31/454;A61K31/593;A61K45/00;A61P15/08;A61P35/00;A61P43/00 主分类号 A61K31/59
代理机构 代理人
主权项
地址