PRODUCTION METHOD OFα,β-DIAMINO ACID HAVING OPTICALLY ACTIVE ASYMMETRIC TETRASUBSTITUTED CARBON

摘要

PROBLEM TO BE SOLVED: To provide an easy and high enantioselective synthesis method ofα,β-diamino acids having an optically active asymmetric tetrasubstituted carbon, or precursors thereof, by a Mannich reaction using anα-isocyanoacetate on ketimines.SOLUTION: An asymmetric catalytic production method of imidazoline as a precursor ofα,β--diamino acids having an optically active asymmetric tetrasubstituted carbon is provided, in which anα-isocyanoacetate is made to react on various ketimines represented by chemical formula (30) below in the presence of a metal species, an asymmetric ligand, and a base.