METHOD FOR TREATING A DISEASE OR DISORDER OF THE LUNG BY INHIBITION OF THE HEDGEHOG PATHWAY

摘要

The present invention is directed to a method of treating a disease or disorder characterised by one or more of the following: decreased lung function, bronchial hyper-responsiveness, hypersecretion of mucus, epithelial cell hyperplasia, smooth muscle hypertrophy, fibrosis or inflammation with an antagonist of a Hedgehog protein, an antagonist of Smoothened, or an antagonist of Gli. The present invention further provides kits for implementing the above method and the use of an antagonist of a Hedge-hog protein, an antagonist of Smoothened, or an antagonist of Gli for treating the above disease or disorder.

主权项

1. A method of treating a disease or disorder characterised by one or more of hypersecretion of mucus, epithelial cell hyperplasia, smooth muscle hypertrophy, fibrosis, inflammation, bronchial hyper-responsiveness or decreased lung function comprising administering a 5E1 monoclonal antibody or a monoclonal antibody which binds the same epitope as 5E1 or a functional antigen binding fragment thereof to a patient in need thereof.