| 发明名称 |
INHIBITION OF TISSUE FACTOR PATHWAY INHIBITOR WITH FACTOR XA DERIVATIVES |
| 摘要 |
The present disclosure relates to compositions and methods for the treatment of bleeding disorders, such as hemophilia A, hemophilia B, von Willebrand (vWF) disease, and factor XII deficiency, by reducing the circulating concentration of tissue factor pathway inhibitor (TFPI), with a factor Xa derivative. |
| 申请公布号 |
US2015352194(A1) |
申请公布日期 |
2015.12.10 |
| 申请号 |
US201314762098 |
申请日期 |
2013.03.13 |
| 申请人 |
PORTOLA PHARMACEUTICALS, INC. |
发明人 |
Lu Genmin;Sinha Uma;Karbarz Mark;Pandey Anjali;Conley Pamela B. |
| 分类号 |
A61K38/48;A61K47/48;A61K45/06 |
主分类号 |
A61K38/48 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating a bleeding disorder in a subject in need thereof, comprising administering to the subject an effective amount of a polypeptide factor Xa (fXa) derivative (a) that comprises a fXa heavy chain that comprises a modification at an active site and (b) that does not include a light chain or comprises a Gla-deficient or des-Gla fXa light chain. |
| 地址 |
South San Francisco CA US |
