发明名称 |
薬物送達デバイス |
摘要 |
<p>The invention provides an implantable intracranial device for the site-specific delivery of a pharmaceutically active agent to a human or animal for treating a mental or neurological disorder, such as Alzheimer's disease, schizophrenia or other psychoses. The biodegradable device includes a pharmaceutically active agent for treating the disorder, polymeric nano-lipoparticles into or onto which the pharmaceutically active agent is embedded; and a polymeric matrix or scaffold incorporating the nano-lipoparticles. The nano-lipoparticles can be in the form of nano-liposhells or nano-lipobubbles. The nano-liposhells or nano-lipobubbles can include an essential fatty acid or can be conjugated to a peptide ligand which targets the device to a specific cell into which the therapeutic agent can be delivered. The device can be implanted in the sub-arachnoid space in the region of the frontal lobe of the brain.</p> |
申请公布号 |
JP5833727(B2) |
申请公布日期 |
2015.12.16 |
申请号 |
JP20140216162 |
申请日期 |
2014.10.23 |
申请人 |
ユニバーシティ・オブ・ザ・ウィットウォータースランド・ヨハネスブルグUNIVERSITY OF THE WITWATERSRAND, JOHANNESBURG |
发明人 |
ゴベンダー,シレセン;ピレイ,ビネス;チューナラ,ヤヒャ・エソップ;デュ・トワ,リサ・クレール;モディ,ギリシュ;ナイドー,ディネシュ;ムファマディ,マルタ・スティーブン |
分类号 |
A61K47/38;A61K9/00;A61K9/48;A61K31/202;A61K31/5415;A61K45/00;A61K47/12;A61K47/34;A61P25/18 |
主分类号 |
A61K47/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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