| 摘要 |
本发明系提供一种在特定的温度、pH下引起亲-疏水变化的共聚物，以及藉由与该共聚物复合化，可在特定温度、pH下释放内包物的脂质体复合物。其为具有来自下述通式(1)表示的单体的重复单元(a)、来自含羧基的单体的重复单元(b)、来自下述通式(2)表示的单体的重复单元(c)的共聚物，以及与该共聚物复合化的脂质体复合物。;(式(1)中，R1表示氢原子或甲基，R2表示碳原子数为1至4的烷基，n表示1至4的自然数。);(式(2)中，R3表示氢原子或甲基，R4表示碳原子数为8至20的烷基或碳原子数为8至20的烯基，m表示1至6的自然数。) The present invention provides a copolymer which can induce hydrophilic-hydrophobic exchange at a specific temperature and pH, and a liposome complex obtained by compositing with the copolymer, which is capable of releasing inclusion at a specific temperature and pH. The copolymer comprises a repeat unit (a) derived from a monomer represented by the following general formula (1), a repeat unit (b) derived from a carboxyl-group-containing monomer, and a repeat unit(c) derived from a monomer represented by the following general formula (2), and a liposome complex obtained by compositing with the copolymer;(In formula (1), R1represent a hydrogen atom or a methyl group, R2represents an alkyl group with a carbon number of 1 to 4, n represent a nature number of 1 to 4.);(In formula (2), R3represent a hydrogen atom or a methyl group, R4represents an alkyl group with a carbon number of 8 to 20 or an alkenyl group with a carbon number of 8 to 20, m represents a nature number of 1 to 6.) |
