发明名称 |
PROCESS FOR PREPARING [(3-HYDROXYPYRIDINE-2-CARBONYL)AMINO]ALKANOIC ACIDS, ESTERS AND AMIDES |
摘要 |
<p>Disclosed are processes for preparing [(3-hydroxypyridine-2-carbonyl)amino]-alkanoic acids, derivatives, inter alia, 5-aryl substituted and 5-heteroaryl substituted [(3-hydroxypyridine-2-carbonyl]amino}acetic acids. Further disclosed are methods for making prodrugs of [(3-hydroxypyridine-2-carbonyl)-amino]acetic acids, for example, [(3-hydroxypyridine-2-carbonyl]amino}acetic acid esters and {[3-hydroxypyridine-2-carbonyl]amino}acetic acid amides. The disclosed compounds are useful as prolyl hydroxylase inhibitors or for treating conditions wherein prolyl hydroxylase inhibition is desired.</p> |
申请公布号 |
EP2718265(B1) |
申请公布日期 |
2015.12.16 |
申请号 |
EP20120796374 |
申请日期 |
2012.06.05 |
申请人 |
AKEBIA THERAPEUTICS INC. |
发明人 |
LANTHIER, CHRISTOPHER, M.;GORIN, BORIS;OUDENES, JAN;DIXON, CRAIG, EDWARD;LU, ALAN, QUIGBO;COPP, JAMES, DENSMORE;JANUSZ, JOHN, MICHAEL |
分类号 |
C07D213/81;C07D213/79;C07D213/803 |
主分类号 |
C07D213/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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