Tamoxifen derivatives intended for the treatment of neoplastic diseases, particularly with higher level of HER2 protein

摘要

The present invention relates to a process for preparing mitochondrially targeted E and/or Z isomers via an aliphatic chain of bonded triphenylphosphonium derivatives of tamoxifen of the general formula I and IA, wherein the meanings of the general substituents are specified in the descriptive section. The derivative of the general formula IA or its corresponding salts of tertiary amine. The invention also relates to the use of this derivative for the treatment of tumors, particularly with higher level of HER2 protein, further to a medicament containing the above-described derivative and intended for the treatment of neoplastic diseases being selected from the group consisting of astrocytoma, neuroblastoma, glioblastoma, mesothelioma, prostate tumor etc.