ANIMAL MODEL FOR USE IN SCREENING OF PROPHYLACTIC AND THERAPEUTIC AGENTS FOR IGE-RELATED DISEASES

摘要

Disclosed is an animal model which is constructed by transplanting IgE-producing vegetative cells in a non-rejecting animal to endow the animal with ability to induce IgE-mediated allergic reaction caused by the transplanted cells, a method of preparing the animal model and a method of screening prophylactic and therapeutic agents for IgE-related diseases. Screening of the prophylactic and therapeutic agents for IgErelated diseases can be efficiently and expediently carried out using the animal model according to the present invention in which IgE-mediated allergic reaction is repeatedly induced by repeated antigen challenge.