Small molecule inhibitors of the E3 Ligase Skp2 in depression and other diseases

摘要

The present invention relates to Skp2 inhibitors for the use in the therapeutic activation of autophagy and especially for use as an antidepressant. Furthermore the present invention refers to a method of determining if a subject suffering from depression responds to an antidepressant and to a method for screening for novel compounds for the therapeutic activation of autophagy which is suitable for different diseases, such as depression.